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Declining shares in the energy and mining sectors contributed to the index being down 0.61 per cent to 4,314.34 points at 11:11 BST, Reuters reports.
Shares in BHP Billiton dropped 1.61 per cent to 1,402p, while Rio Tinto slipped 1.62 per cent to 2,123p.
There were also falls for Royal Dutch Shell and investment services company Schroders, which dropped 3.23 per cent to 824p.
Market analyst Joshua Raymond noted that many investors were seeking to take profits following the rise on the FTSE yesterday.
"Energy and mining stocks led yesterday's rally and so naturally these are the two sectors investors have taken their profits from," he explained.
Mr Raymond added that trading tomorrow is likely to be "extremely quiet", as there will be fewer buyers operating due to the US markets being closed ahead of the Independence Day celebrations.
